Xtra-Cell Anti-Aging Support is manufactured and purified via a patented † low temperature process that involves homogenization, fractionation, and ultrafiltration of porcine and marine tissues. The molecules present in this product are selected based on their size and molecular weight, and are isolated in their native state. Compounds found in the mesenchyme, adrenal and thymus are typically less than 50,000 Daltons, while the compounds present in the marine cartilage extract are less than 500,000 Daltons. Once the molecules are selected, the liquid is aseptically bottled and flash-frozen without preservatives to ensure optimal potency, freshness and bioavailability. This process can be applied to different starting materials, allowing for the creation of liquid extracts that are targeted for specific applications. The extracts created from these tissues are highly bioavailable and of the highest quality available. Supplementing with adrenal extract may help to stimulate the adrenal gland. The unique organ-specific glandular growth factors and signaling molecules present in the adrenal and mesenchyme extracts in Xtra-Cell Anti-Aging Support help to promote healthy adrenal function, improve cellular activity, and promote homeostasis, all of which can contribute to healthy aging.* Mesenchyme is embryonic connective tissue composed of pluripotent cells, or cells that are undifferentiated and have the ability to evolve into almost any type of cell. The material used in Xtra-Cell Anti-Aging Support is obtained from fetal porcine mesenchymal tissue from which cellular growth factors and other signaling molecules are extracted. In vitro data have demonstrated that the components present in the mesenchyme extract can increase cellular metabolism as demonstrated by significant increases in fibroblast mitochondrial activity in the presence of presence of unaffected cellular proliferation (figures 1 and 2). The combination of adrenal and mesenchyme extracts in Xtra-Cell Anti-Aging Support synergistically provides nutritional support for fatigue, and helps to support healthy adrenal function.* Xtra-Cell Anti-Aging Support also provides thymus extract containing a broad range of thymic peptides and may play important roles in supporting lymphocyte proliferation and maturation, thus helping to support overall immune function. Liquid cartilage extract contains numerous peptides Douglas Laboratories ® P Product Data Douglas Laboratories ® P (continued on reverse) and other signaling factors that may help to maintain the structure and function of the extracellular matrix as well as support joint and connective tissues, all of which contribute to healthy aging. Compounds present in LCE can help to support the proper activity of a family of zinc-dependent enzymes known as matrix metalloproteinases (MMPs).* Specifically, MMP-2 MMP-9, and MMP-12 (also know as gelatinase A gelatinase B, and metalloelastase, respectively) have been shown to be involved in the breakdown of skin collagen fibers, vascular basement membranes, and cartilage. Figures 3 and 4 show that LCE can support healthy MMP activity, which may in turn helps support healthy aging.